Thursday June 17th, 2021
| 12.30-12.40 | Welcome |
| 12.40-12.50 | Introduction Willeke la Fontaine (KWF) |
| 12.50-13.00 | Miltenyi Biotech |
| 13.00-14.15 | Oral presentation Session 1 |
| 5 talks selected from proffered abstracts Of note: Exactly 10 min per (pre-recorded) abstract presentation followed by 15-20 min Q&A in real-time/online after each session. Audience Engagement will be available throughout the whole program • The tumor immune microenvironment is decisive in the survival of pancreatic ductal adenocarcinoma Dana A.M. Mustafa, Erasmus MC • Pre-existing tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma Micaela Harrasser, Amsterdam UMC • Chemokine-driven spatial organization of immune cell microaggregates marks oropharyngeal squamous cell carcinomas containing tumor-specific T cells Ziena Abdulrahman, PhD candidate, LUMC • High dimensional analysis of the human lymph node during melanoma progression reveals shifts in myeloid content that relate to differential T cell content Anastasia Prokopi, Amsterdam UMC • Transcriptomic profile representing disbalance between stromal and T cells potentially improves selection of metastatic urothelial cancer patients for pembrolizumab treatment Maud Rijnders, PhD candidate, Erasmus MC | |
| 14.15-14.30 | Coffee/Tea Break |
| 14.30-15.45 | Oral presentation Session 2 |
| 5 talks selected from proffered abstracts • Exploiting pre-existing inflationary anti-CMV immunity to attack cancer cells Isabel Britsch, PhD candidate, UMCG • Developing cancer vaccines to improve immune checkpoint blockade efficacy Melisa D. Castro Eiro, Erasmus MC • MR-guided thermal and mechanical high-intensity focused ultrasound ablation: effects on tumor destruction and immune cell activation Vera E. Mekers, PhD candidate, Radboudumc • EGFR-directed blockade of the CD73-adenosine immune checkpoint Emily M. Ploeg, PhD candidate, UMCG • Targeting LAIR-1 and the PD-L1/PD-1 axis as novel combination cancer immunotherapy Akashdip Singh, PhD candidate, UMC Utrecht | |
| 15.45-16.00 | Coffee/Tea Break |
| 16.00-16.45 | Oral presentation Session 3 |
| 3 talks selected from proffered abstracts • TME Analyzer: a novel multi-dimensional visualization and analysis tool to identify immune contexture-based predictors in tumors Hayri E. Balcioglu, Erasmus MC • CD169 defines activated CD14+ monocytes with enhanced CD8+ T cell activation capacity Alsya J. Affandi, Amsterdam UMC • Cancer cells resist therapeutic antibody-mediated destruction by neutrophils Panagiota Bouti, PhD candidate, Sanquin | |
| 16.45-17.30 | Keynote speaker |
| Prof. Liesbeth de Vries | |
| Medical Oncology, University Medical Center Groningen, NL | |
| Molecular imaging for immunotherapy | |
| 17.30-18.00 | Drinks/Bites and Biobreak |
| 18.00-19.45 | Escape room: Project Pegasus Hosted by UP events |
Friday June 18th, 2021
| 9.00-10.15 | Oral presentation Session 4 |
| 5 talks selected from proferred abstracts Of note: Exactly 10 min per (pre-recorded) abstract presentation followed by 15-20 min Q&A in real-time/online. Audience Engagement will be available throughout the whole program • Combining a CAR and a chimeric costimulatory receptor simultaneously enhances T cell sensitivity to low antigen density and persistence Afroditi Katsarou, PhD candidate, Amsterdam UMC • Cytokine-producing tumor-infiltrating lymphocyte products can be effectively generated from pre-treated late stage non-small-cell lung cancer (NSCLC) lesions irrespective of location and pre-treatment regimens Suzanne M. Castenmiller, PhD candidate, Sanquin • Pan-cancer expression of Cancer Germline Antigens is related to mechanisms of T cell evasion Dian Kortleve, PhD candidate, Erasmus MC • Expanding the repertoire of HLA class I-restricted minor histocompatibility antigens for immune monitoring and modulation after allogeneic stem cell transplantation Kyra J. Fuchs, PhD candidate, LUMC • Production and testing of a novel bispecific nanobody construct targeting NK cells and EGFR expressing malignancies Elisa C. Toffoli, PhD candidate, Amsterdam UMC | |
| 10.15-10.30 | Coffee/Tea Break |
| 10.30-11.30 | Oral presentation Session 5 |
| 4 talks selected from proferred abstracts • Sialic acid blockade in BMDC enhances CD8+ T cell responses by facilitating high avidity DC- T cell interactions Lenneke A.M. Cornelissen, Radboudumc • A novel cancer immunotherapy; vaccination against tumor vascular extracellular Vimentin Else J.M. Huijbers, Amsterdam UMC • Galectin-mediated interactions are essential in governing dendritic cell anti-melanoma immunity Laia Querol Cano, Radboudumc • Expression of neolacto-series glycosphingolipids by tumors impairs the function of low-affinity immune receptor-ligand pairs Tamara Verkerk, PhD candidate, Sanquin | |
| 11.30-12.15 | Keynote speaker |
| Prof. Jannie Borst | |
| Immunology, Leiden University Medical Center, NL | |
| How to cure CTL dysfunction? | |
| 12.15-12.30 | Coffee/ Tea break |
| 12.30-13.15 | Coffee/ Tea break Speed dating network event |
| 13.15-13.25 | AIO Award Ceremony Closure |